Protein Details: Voltage-gated sodium channel subunit beta-1

Protein ID

ICDB_Pro_0724

Protein Name

Voltage-gated sodium channel subunit beta-1

Gene Name

Scn1b

Organism

Mus musculus (Mouse)

Length

218 amino acids

AlphaFoldDB

AF-P97952-F1-model_v4.pdb

Function

Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain; heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits; such as SCN1A; SCN2A; SCN3A; SCN4A; SCN5A and SCN10A.

Sequence

MGTLLALVVGAALVSSAWGGCVEVDSDTEAVYGMTFKILCISCKRRSETTAETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFDNYEHNTSVVKKIHLEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMVYCYKKIAAATEAAAQENASEYLAITSESKENCTGVQVAE

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Detected in hippocampus CA3 bipolar neurons (at protein level). Detected in skeletal muscle.

DOI ID

10.1016/s0169-328x(96)00123-4; 10.1161/01.res.83.4.441; 10.1101/gr.2596504; 10.1523/jneurosci.2475-09.2009; 10.1016/j.cell.2010.12.001

RefSeq

NP_035452.1